Classical ranking-and-selection (R&S) procedures cannot be applied directly to select the best decision in the presence of distributional ambiguity. In this paper we propose a robust selection of the best (RSB) framework which compares decisions based on their worst-case performances over a finite set of possible distributions and selects the decision with the best worst-case performance. To solve the RSB problems, we design a two-layer R&S procedure under the indifference-zone formulation. The procedure identifies the worst-case distribution in the first stage and the best decision in the second. We prove the statistical validity of the two-layer procedure and test its performance numerically.